Study archive · page 6

In older people with sarcopenia, resistance training and mixed training significantly improved knee-extension strength and gait speed, while whole-body vibration training improved neither. Chair-stand times did not improve with any exercise mode.

⚠What it shows: Meta-analysis of 26 studies (25 RCTs plus one non-randomised trial, 1,191 older adults with sarcopenia); heterogeneity was high in several analyses and chair-stand performance did not improve with any mode.Meta-analysis · BMC Geriatr

A network meta-analysis of 89 studies in chronic non-specific low back pain ranked Pilates most likely to reduce pain, with resistance and motor-control exercise best for physical function. Stretching and McKenzie exercise did not outperform doing nothing.

⚠What it shows: Network meta-analysis of 89 studies (5,578 patients), but the synthesised evidence was rated low quality under GRADE, with high heterogeneity and few low-risk-of-bias trials — rankings are indicative, not definitive.Meta-analysis · Br J Sports Med

Mind-body exercise such as yoga, tai chi, Pilates and qigong improved bone mineral density, sleep quality, anxiety, depression and fatigue in perimenopausal and postmenopausal women across 11 randomised trials.

⚠What it shows: Meta-analysis of 11 RCTs (1,005 women); heterogeneity was high for the sleep, anxiety and depression outcomes; effects are standardised differences, so the real-world size of the benefit is unclear.Meta-analysis · Menopause

Pooling 20 studies in musculoskeletal rehabilitation, low-load training with blood flow restriction produced a moderate strength gain (Hedges' g=0.523) and was more effective and more tolerable than low-load training alone — but heavy-load training still produced the larger effect (g=0.674).

⚠What it shows: Systematic review and meta-analysis of 20 studies, mostly small: ACL reconstruction (n=3), knee osteoarthritis (n=3), older adults at risk of sarcopenia (n=13) and one inclusion body myositis study — not trained athletes. The authors note cuff prescription is not yet individualised.Meta-analysis · Br J Sports Med

A Cochrane review of 121 randomised trials and 6700 older adults found progressive resistance training produced a large improvement in muscle strength and smaller but real gains in physical ability, gait speed and getting out of a chair. Pain fell in participants with osteoarthritis, though not in other trials of bodily pain.

⚠What it shows: Cochrane systematic review and meta-analysis of 121 RCTs, 6700 participants; the strength effect was large (SMD 0.84) but the gain in physical ability was small (SMD 0.14), and adverse events were poorly recorded, with joint pain and muscle soreness commonly reported where they were tracked.Meta-analysis · Cochrane Database Syst Rev

Across 51 randomised trials, mind-body, resistance, flexibility and coordination exercise were all associated with reduced functional disability from nonspecific neck pain. An exploratory analysis suggested benefits from around 100 MET-min per session, with larger effects around 300-400 MET-min.

⚠What it shows: Network meta-analysis of 51 RCTs (4,140 participants); interventions were heterogeneous and the dose-response analysis is exploratory, study-level data only.Meta-analysis · PeerJ

In a randomised trial of 142 healthy older adults, six months of foreign-language learning kept the CA3/dentate gyrus region of the hippocampus stable while the non-language groups lost volume, whereas aerobic exercise — not language — improved memory precision on a mnemonic discrimination task. Combining both was the only way to get both effects, but the combination did not amplify either one.

⚠What it shows: One six-month randomised controlled trial in 142 healthy adults aged 63-78 with four groups, so roughly 35 people per arm; brain volume changes were not actually linked to memory changes, and the findings need replication before anyone claims a protocol for protecting the ageing hippocampus.Study · Imaging Neurosci (Camb)

In adults diagnosed with depression or anxiety, exercise produced a large improvement in depressive symptoms and a moderate improvement in anxiety symptoms across randomised trials. Aerobic, resistance and mixed programmes were all beneficial.

⚠What it shows: Meta-analysis of 26 RCTs (2,681 participants) in adults with diagnosed depression or anxiety; the anxiety analysis rested on only 11 studies, and the review could not crown a single best exercise mode.Meta-analysis · Int J Ment Health Nurs

An umbrella review pooling 133 systematic reviews and 2,724 randomised trials found exercise improves general cognition, memory and executive function across all populations and ages. Effects were generally larger for low- and moderate-intensity activity.

⚠What it shows: Umbrella review of 258,279 participants; effects were modest in size (SMD 0.24-0.42), overlap between the included reviews is inherent to the design, and review quality varied — though results held after excluding low-quality reviews.Meta-analysis · Br J Sports Med

Across 41 randomised trials in 2,264 adults, exercise produced large reductions in depressive symptoms compared with non-active controls, with a number needed to treat of 2. The effect remained moderate when analysis was restricted to the 12 low risk-of-bias trials.

⚠What it shows: Meta-analysis of 41 RCTs (2,264 participants post-intervention); many trials were small with high heterogeneity in methods, and the effect shrank to moderate in the 12 low risk-of-bias studies.Meta-analysis · Br J Sports Med

Exercise programmes produced a small but significant improvement in working memory in adults with mild-to-moderate depression. Effects on inhibition and cognitive flexibility, two other core executive functions, were not significant.

⚠What it shows: Meta-analysis of only 7 controlled studies (202 men, 457 women, aged 21-51, mild-to-moderate depression); high heterogeneity across trials; the authors say the shortage of high-quality studies precludes firm conclusions.Meta-analysis · Int J Environ Res Public Health

Pooling 54 randomised trials in healthy children, adults and older adults, exercise improved overall cognition and every domain measured, with aerobic work showing the greatest benefit for global cognition, resistance training for executive function and mind-body exercise for memory. Older adults gained the most.

⚠What it shows: Systematic review and meta-analysis of 54 RCTs in healthy people; the type-by-domain comparisons come from moderation analyses across studies rather than head-to-head trials, and the authors say evidence on attention and information processing is still too thin to judge.Meta-analysis · Ageing Res Rev

Across 49 randomised trials with 1863 healthy adults, adding protein supplements to resistance training increased fat-free mass by 0.30 kg and one-rep-max strength by 2.49 kg on average. Once total protein intake passed roughly 1.62 g/kg/day, extra protein added nothing further to fat-free mass gains.

⚠What it shows: Meta-analysis of 49 RCTs in healthy adults training for at least six weeks, so the pooled effects are solid but small in absolute terms; the 1.62 g/kg/day ceiling comes from a break-point analysis of group averages, not an individualised threshold, and the senior author discloses dairy-industry grant support.Meta-analysis · Br J Sports Med

A meta-analysis of 74 randomised trials found that eating more protein adds small extra gains in lean mass and lower-body strength for healthy adults doing resistance training. Lean-mass benefits appeared at 1.2-1.59 g of protein per kg per day in adults 65 and over, and at 1.6 g/kg/day or more in younger adults.

⚠What it shows: Meta-analysis of 74 RCTs in healthy, non-obese adults; the lean-mass effect was small (SMD 0.22, moderate-level evidence), strength evidence was rated low, and some authors have food-industry ties.Meta-analysis · J Cachexia Sarcopenia Muscle

A network meta-analysis of 92 trials in adults aged 55-70 with overweight or obesity found that combining calorie restriction with resistance or mixed exercise and high protein intake was the most effective strategy for nearly all body-composition outcomes. Energy restriction alone was less effective and tended to decrease muscle mass.

⚠What it shows: Network meta-analysis of RCTs: 92 studies included, 66 of them (4,957 participants) usable for pooling; interventions lasted only 8 weeks to 6 months, and network comparisons are partly indirect.Meta-analysis · Adv Nutr

A four-arm trial in 44 men with obesity found that 12 weeks of combined aerobic-resistance training plus 3 g/day taurine produced the biggest shifts: body mass -5.50 kg, body fat -4.90%, lower asprosin and higher spexin. Training alone or taurine alone did less, and the untreated control group changed on nothing.

⚠What it shows: Four-arm randomised trial with only n=11 per group in men with a BMI of at least 30; supplement-blinded rather than fully double-blind, and the authors themselves call the results preliminary and exploratory pending larger replication.Study · Nutrients

A meta-analysis of 10 randomised trials using direct muscle imaging found that adding creatine to resistance training produces only a very small extra increase in muscle size compared with training plus placebo. Gains in upper- and lower-body muscle thickness were in the region of 0.10-0.16 cm.

⚠What it shows: Meta-analysis of 10 RCTs (44 outcomes) in healthy adults; the pooled effect was very small and its credible interval crossed zero; several authors declared ties to the creatine industry.Meta-analysis · Nutrients

In a meta-analysis of 10 randomised trials with 1,154 participants, whey protein supplementation improved muscle mass and gait speed in older adults diagnosed with sarcopenia, and combining it with resistance training significantly increased handgrip strength.

⚠What it shows: Meta-analysis of 10 RCTs (1,154 older adults with diagnosed sarcopenia, community and hospital settings mixed); the authors say more studies are needed to validate the results.Meta-analysis · J Nutr Health Aging

Across 93 randomised trials, endurance, dynamic resistance and isometric resistance training all lowered resting blood pressure, with isometric training showing the largest systolic reduction at -10.9 mm Hg. Endurance training worked best in people who already had hypertension.

⚠What it shows: Meta-analysis of 93 trials (5,223 participants), but the standout isometric figure rests on only 5 training groups, so the comparison between modes is far less certain than the overall benefit.Meta-analysis · J Am Heart Assoc

'Exercise snacks' — bouts lasting 5 minutes or less, done at least twice a day — significantly improved cardiorespiratory fitness in physically inactive adults across 11 randomised trials. They did not improve blood pressure, body composition or blood lipids.

⚠What it shows: Meta-analysis of 11 RCTs with only 414 participants (69.1% women); the fitness result had moderate certainty with high heterogeneity, and the older-adult endurance finding was rated very low certainty.Meta-analysis · Br J Sports Med

Exercise-based treatments reduced pain and disability in athletes with low back pain, but no trial reported whether athletes actually returned to sport, and it remains unclear which treatment works best for whom.

⚠What it shows: Meta-analysis of 14 RCTs (541 athletes) with performance, attrition and reporting biases; no return-to-sport data for any exercise intervention; insufficient evidence for manual therapy or biomechanical changes alone.Meta-analysis · Br J Sports Med

Delaying morning training from 07:00 to 09:00 gave national-level swimmers 1.0 h more sleep per night on average — but recovery and 100 m and 800 m time-trial performance did not measurably improve over the 8-day camps.

⚠What it shows: One cross-over RCT in 27 adolescent national-level swimmers across two 8-day training camps; the extra sleep produced no significant recovery or performance change in that short window, and results may not generalise to older or recreational athletes.Study · Sports Med Open

Adults over 60 who stay physically active show lower risks of all-cause and cardiovascular mortality, breast and prostate cancer, fractures, recurrent falls, disability, cognitive decline, dementia and depression than inactive peers.

⚠What it shows: Umbrella review of 24 systematic reviews of longitudinal observational studies in adults 60+; these are associations, not proof that activity causes the better outcomes, and the review does not specify how much activity is needed.Systematic review · Scand J Med Sci Sports

In adults with prediabetes or type 2 diabetes, intermittent fasting cut body weight by 4.56 kg and lowered HbA1c, fasting glucose, cholesterol and triglycerides versus control diets — but against straightforward calorie restriction it added only modest extra weight loss and no metabolic advantage.

⚠What it shows: Meta-analysis of 14 randomised trials (1,101 adults with prediabetes or type 2 diabetes); fat mass, insulin, LDL, HDL and blood pressure did not improve versus control, and versus calorie restriction there were no differences in glycaemic markers, lipids or blood pressure.Meta-analysis · Diabetes Obes Metab