Fisetin
Bronze· animal data onlyA senolytic flavonoid with exciting animal data but almost no human outcome evidence yet.
Fisetin is a flavonoid (found in strawberries) that gained attention as a 'senolytic' — a compound that helps clear senescent 'zombie' cells thought to drive ageing.
In mice, intermittent high-dose fisetin cleared senescent cells and extended healthspan, which is genuinely striking. But human evidence is almost absent; clinical trials are only now underway, so buying it for anti-ageing is acting well ahead of the data. Bioavailability is also poor.
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Written and reviewed by Mathew Beale, MSc Biotechnology, University of Reading.
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