UC-II (undenatured type II collagen)
Silver· human dataAlso known as: Undenatured collagen
A low-dose collagen that may ease joints by a different route than collagen peptides.
UC-II is a small daily dose of undenatured type II collagen thought to work not as a building block but by an immune-tolerance mechanism in the gut that calms joint inflammation — a different route from high-dose collagen peptides.
A handful of small trials suggest it may improve knee-osteoarthritis symptoms and exercise-related joint comfort, in some cases outperforming glucosamine-and-chondroitin. The evidence base is small and often industry-linked, so treat it as promising rather than proven.
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Written and reviewed by Mathew Beale, MSc Biotechnology, University of Reading.
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